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Karlene is an English feminine elaboration of Karl, which derives from the Old High German word karl, meaning free man or simply man. The name follows a common pattern of feminizing Germanic names by adding the suffix -ene or -ine, and it emerged primarily in the twentieth century in English-speaking countries. Related forms include Karla, Carla, Carlene, and Charlene, all of which trace back ultimately to the same Germanic root that also gave rise to the Latin Carolus and the royal name Charles.